Journal article
C. Härtel, J. Spiegler, Ingmar Fortmann, M. Astiz, H. Oster, Bastian Siller, D. Viemann, T. Keil, T. Banaschewski, M. Romanos, E. Herting, W. Göpel
Nutrients, 2020
Nutrients, 2020
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APA
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Härtel, C., Spiegler, J., Fortmann, I., Astiz, M., Oster, H., Siller, B., … Göpel, W. (2020). Breastfeeding for 3 Months or Longer but Not Probiotics Is Associated with Reduced Risk for Inattention/Hyperactivity and Conduct Problems in Very-Low-Birth-Weight Children at Early Primary School Age. Nutrients.
Chicago/Turabian
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Härtel, C., J. Spiegler, Ingmar Fortmann, M. Astiz, H. Oster, Bastian Siller, D. Viemann, et al. “Breastfeeding for 3 Months or Longer but Not Probiotics Is Associated with Reduced Risk for Inattention/Hyperactivity and Conduct Problems in Very-Low-Birth-Weight Children at Early Primary School Age.” Nutrients (2020).
MLA
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Härtel, C., et al. “Breastfeeding for 3 Months or Longer but Not Probiotics Is Associated with Reduced Risk for Inattention/Hyperactivity and Conduct Problems in Very-Low-Birth-Weight Children at Early Primary School Age.” Nutrients, 2020.
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@article{c2020a,
title = {Breastfeeding for 3 Months or Longer but Not Probiotics Is Associated with Reduced Risk for Inattention/Hyperactivity and Conduct Problems in Very-Low-Birth-Weight Children at Early Primary School Age},
year = {2020},
journal = {Nutrients},
author = {Härtel, C. and Spiegler, J. and Fortmann, Ingmar and Astiz, M. and Oster, H. and Siller, Bastian and Viemann, D. and Keil, T. and Banaschewski, T. and Romanos, M. and Herting, E. and Göpel, W.}
}
Abstract
(1) Background: We aimed to evaluate the effect of proposed “microbiome-stabilising interventions”, i.e., breastfeeding for ≥3 months and prophylactic use of Lactobacillus acidophilus/ Bifidobacterium infantis probiotics on neurocognitive and behavioral outcomes of very-low-birthweight (VLBW) children aged 5–6 years. (2) Methods: We performed a 5-year-follow-up assessment including a strength and difficulties questionnaire (SDQ) and an intelligence quotient (IQ) assessment using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI)-III test in preterm children previously enrolled in the German Neonatal Network (GNN). The analysis was restricted to children exposed to antenatal corticosteroids and postnatal antibiotics. (3) Results: 2467 primary school-aged children fulfilled the inclusion criteria. In multivariable linear regression models breastfeeding ≥3 months was associated with lower conduct disorders (B (95% confidence intervals (CI)): −0.25 (−0.47 to −0.03)) and inattention/hyperactivity (−0.46 (−0.81 to −0.10)) as measured by SDQ. Probiotic treatment during the neonatal period had no effect on SDQ scores or intelligence. (4) Conclusions: Prolonged breastfeeding of highly vulnerable infants may promote their mental health later in childhood, particularly by reducing risk for inattention/hyperactivity and conduct disorders. Future studies need to disentangle the underlying mechanisms during a critical time frame of development.
